ukwelashwa kokukhanya okubomvu emahhashini1

Ukuguqulwa kwe-Photobio, okubizwa ngokuthi ukwelashwa kokukhanya okubomvu ngokwezokwelapha, kusebenza ngokuletha ubude besikhathi bokukhanya obuthile, ngokuvamile ngaphakathi kwebanga le-nanometer engu-630850, ezicutshini ze-equine. Lawa ma-photon amuncwa yi-cytochrome c oxidase, i-enzyme ye-mitochondrial. Lokhu kusebenzisana kuvuselela uchungechunge lokuthuthwa kwama-electron, kuthuthukisa ukwakheka kwe-adenosine triphosphate (ATP) futhi kuqalise uchungechunge lwezehlakalo zokubonisana kwangaphakathi kweseli. Okubalulekile phakathi kwalokhu ukwandiswa kwe-nitric oxide, okuthuthukisa ukujikeleza kwegazi kwendawo futhi kunciphise ukucindezeleka kwe-oxidative. Lokhu kuvuselelwa kwe-bio okuyisisekelo kuvuselela izindlela zokulungisa amaseli, kunciphisa ama-cytokine abangela ukuvuvukala, futhi kukhuthaze imisebenzi yokusebenza efana nokwanda kwe-fibroblast kanye nokwakheka kwe-collagen. Impendulo yomshini ehlangene inikeza isizathu sesayensi sezinzuzo zomtholampilo ezibonwe ezicutshini zemisipha nemisipha, kufaka phakathi imisipha, imisipha, kanye namathambo.

Ukuhlola Ubufakazi Besisekelo Sokuguqulwa Kwezithombe Zezinqola Zezinqola

Ucwaningo lwezilwane olubuyekezwe ontanga luqinisekisa amandla okwelapha e-photobiomodulation, yize ludinga ukuqinisekiswa okuqinile kwezokwelapha. Izifundo ezilawulwayo zibonisa ukuthi ubude bamaza obufana no-660 nm (obomvu) no-850 nm (oseduze ne-infrared) bungaguqula kakhulu ukuqonda kobuhlungu, busheshise umsebenzi we-tendon fibroblast, futhi buthuthukise i-epithelialization yamanxeba. Ukusebenza kahle kokwelapha kuncike kakhulu ekuletheni ubuningi bamandla obunembile (obulinganiswa ngama-Joules ngesentimitha lesikwele), kanye nezinqubo ezilungiselelwe ngokucophelela ukujula, ukugula okungapheli, kanye nohlobo lwe-pathology. Ngenkathi izifundo ze-in vitro kanye ne-in vivo ziveza ubufakazi obunamandla bokusebenza, insimu iyavuma isidingo sezivivinyo zemitholampilo ezinkulu, ezingahleliwe, nezingaboni. Lokhu kubalulekile ukusungula ngokuqinisekile imingcele yokwelashwa, ukuhlukanisa imiphumela yokwelapha kwi-placebo, kanye nokulinganisa imiphumela kuzo zonke izimo ze-equine ezahlukahlukene.

Ukuhlanganiswa Kwezokwelapha: Izicelo Ezihlelekile Ekuvuseleleni

Inzuzo eyinhloko yezokwelapha ye-photobiomodulation itholakala ekuhlanganisweni kwayo ohlelweni lokuvuselela oluhlelekile, ikakhulukazi ekuphatheni ukulimala kwezicubu ezithambile ezingaba khona. Izimo ezifana ne-tendinopathy, i-desmitis, kanye nokuhlukumezeka kwe-myofascial zibonisa izimpendulo ezinhle ezihlala njalo lapho zelashwa ngesikhathi sesigaba sokuvuselela ngemuva kokuncipha kokuvuvukala kokuqala kodwa ngaphambi kokusungulwa koshintsho lwe-fibrotic chronic. Ukusetshenziswa okuphumelelayo kudinga ukuqonda okuningiliziwe kwempendulo yedosi ye-biphasic, lapho amazinga wamandla we-supratherapeutic angakhiqiza imiphumela yokuvimbela. Ngakho-ke odokotela kumele bahlele i-photobiomodulation ngokucophelela kanye nezindlela ezengeziwe kufaka phakathi i-cryotherapy elawulwayo, ukwelashwa ngesandla, kanye nokuzivocavoca okuphothuliwe ukudala iphrothokholi yokusebenzisana ethuthukisa ukulungiswa kwezicubu kanye nokululama kokusebenza.

Ukuphepha Nokuphathwa Kwezinqubo Emisebenzini Yezokwelapha

Ukusetshenziswa Kobuchwepheshe: Ukukhethwa Kwedivayisi kanye Nezimo Zokwelapha

Imiphumela yokwelapha ephumelelayo incike ekusebenzeni okunembile kobuchwepheshe. Ukukhethwa kwamadivayisi kufanele kubeke phambili amayunithi anomkhiqizo oqinisekisiwe, olinganisiwe wamaza okuqondiwe ngokuvamile angu-650 nm ezakhiweni ezingaphezulu kanye no-810 nm wezicubu ezijulile kanye nobuningi bamandla obuhambisanayo kanye nama-timer e-dosimetry ahlanganisiwe. Ukulungiselela ukwelashwa kwangaphambi kokwelashwa kuvame ukufaka phakathi ukunqunywa kwejazi ukuze kuncishiswe ukusabalala kwe-photon nokuqinisekisa ukulethwa kwamandla okuqhubekayo kungqimba lwesikhumba. Indlela yokusebenzisa idinga ukugcina ukuxhumana kwe-probe okuqondile nokulandela iphethini yegridi ehlelekile ukuqinisekisa ukumbozwa kwezicubu okufanayo. Ukwelashwa kumele kuqondiswe yiphrothokholi esekelwe ebufakazini, kuqaphela ukuthi impendulo yezinto eziphilayo ayiqondile nokuthi amandla amaningi awalingani nokusebenza kahle okukhulu. Ukuhlolwa okuqhubekayo kokubekezelelana kwesiguli kanye nokusabela kwezicubu kubalulekile kulo lonke uchungechunge lokwelashwa.

Ukuhlaziywa Kokwelapha Okuqhathanisayo: Indlela Ehambisanayo Neyodwa

Ukuguqulwa kwe-Photobio kumelela ushintsho olujwayelekile oluvela ekunakekelweni kokunciphisa ubuhlungu kuphela kuya ekungeneleleni kwamaseli okusebenzayo. Izindlela zendabuko ezifana nezidakamizwa ezingezona eze-steroidal ezilwa nokuvuvukala (ama-NSAID) kanye ne-cryotherapy ngokuyinhloko zinikeza impumuzo yezimpawu ngokucindezela ukuvuvukala nobuhlungu. Ngokuphambene nalokho, ukuguqulwa kwe-photobio kusebenza ezingeni eliyisisekelo, le-metabolic ngokuthuthukisa ukuphefumula kwe-mitochondrial kanye nekhono le-redox yamaseli. Lesi senzo sisekela uchungechunge lokuphulukisa lwe-endogenous, okwenza kube yinto enamandla, engeyona eyemithi. Kungasheshisa ukulungiswa komzimba, kunciphise ukuncika emithini yesistimu, futhi kuthuthukise ikhwalithi yezicubu ezitholakele. Ukusetshenziswa kwayo okuhle akutholakali njengokufaka esikhundleni sokwelashwa okuvamile, kodwa njengengxenye ehambisanayo ngaphakathi kwesu lokuvuselela elinolwazi oluningi ngebhayoloji.